Mitogen-activated protein kinases as therapeutic targets in osteoarthritis
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منابع مشابه
Mitogen-activated Protein Kinases in Inflammation
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective response of host against microbial infection. Controlled inflammation is beneficial and necessary for host defense while uncontrolled inflammatory response res...
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Previous studies suggested that tyrosine kinase activation is an important signal transduction event in the IL-1 response of chondrocytes. The present study identifies the mitogenactivated protein (MAP) kinases extracellular signal-regulated kinase (ERK)-1 and ERK-2 as major tyrosine phosphorylated proteins in IL-1 stimulated chondrocytes. Kinase assays on immunoprecipitates with myelin basic p...
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Given the prevalence and debilitating nature of chronic inflammatory diseases there is a never ending quest for identification of novel targets for the rational development of anti-inflammatory drugs. Although the major signalling pathway that controls inflammation associated gene expression is the one leading to activation of transcription factor NF-kappaB, considerable attention has also been...
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Protozoan pathogens are a highly diverse group of unicellular organisms, several of which are significant human pathogens. One group of protozoan pathogens includes obligate intracellular parasites such as agents of malaria, leishmaniasis, babesiosis, and toxoplasmosis. The other group includes extracellular pathogens such as agents of giardiasis and amebiasis. An unfortunate unifying theme for...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2008
ISSN: 1040-8711
DOI: 10.1097/bor.0b013e3283090463